MersV1, Main, Exploration, bibRecord, 001F43

Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation

Identifieur interne : 001F43 ( Main/Exploration ); précédent : 001F42; suivant : 001F44

Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation

Auteurs : Bart L. Haagmans [Pays-Bas] ; Said H S. Al Dhahiry [Qatar] ; Chantal B E M. Reusken [Pays-Bas] ; V Stalin Raj [Pays-Bas] ; Monica Galiano [Royaume-Uni] ; Richard Myers [Royaume-Uni] ; Gert-Jan Godeke [Pays-Bas] ; Marcel Jonges [Pays-Bas] ; Elmoubasher Farag [Qatar] ; Ayman Diab [Qatar] ; Hazem Ghobashy [Qatar] ; Farhoud Alhajri [Qatar] ; Mohamed Al-Thani [Qatar] ; Salih A. Al-Marri [Qatar] ; Hamad E. Al Romaihi [Qatar] ; Abdullatif Al Khal [Qatar] ; Alison Bermingham [Royaume-Uni] ; Albert D M E. Osterhaus [Pays-Bas] ; Mohd M. Alhajri [Qatar] ; Marion P G. Koopmans [Pays-Bas]

Source :

The Lancet. Infectious Diseases [ 1473-3099 ] ; 2013.

RBID : PMC:7106553

Descripteurs français

KwdFr :
- ARN viral (analyse), Adulte, Adulte d'âge moyen, Analyse de séquence d'ARN, Animaux, Chameaux (virologie), Coronavirus (génétique), Coronavirus (isolement et purification), Données de séquences moléculaires, Flambées de maladies (médecine vétérinaire), Humains, Infections à coronavirus (diagnostic), Infections à coronavirus (médecine vétérinaire), Infections à coronavirus (virologie), Infections à coronavirus (épidémiologie), Mâle, Phylogénie, Qatar (épidémiologie), RT-PCR, Réservoirs d'agents pathogènes (virologie), Séquence nucléotidique, Zoonoses (diagnostic), Zoonoses (virologie), Zoonoses (épidémiologie).
MESH :
- analyse : ARN viral.
- diagnostic : Infections à coronavirus, Zoonoses.
- génétique : Coronavirus.
- isolement et purification : Coronavirus.
- médecine vétérinaire : Flambées de maladies, Infections à coronavirus.
- virologie : Chameaux, Infections à coronavirus, Réservoirs d'agents pathogènes, Zoonoses.
- épidémiologie : Infections à coronavirus, Qatar, Zoonoses.
- Adulte, Adulte d'âge moyen, Analyse de séquence d'ARN, Animaux, Données de séquences moléculaires, Humains, Mâle, Phylogénie, RT-PCR, Séquence nucléotidique.

English descriptors

KwdEn :
- Adult, Animals, Base Sequence, Camelus (virology), Coronavirus (genetics), Coronavirus (isolation & purification), Coronavirus Infections (diagnosis), Coronavirus Infections (epidemiology), Coronavirus Infections (veterinary), Coronavirus Infections (virology), Disease Outbreaks (veterinary), Disease Reservoirs (virology), Humans, Male, Middle Aged, Molecular Sequence Data, Phylogeny, Qatar (epidemiology), RNA, Viral (analysis), Reverse Transcriptase Polymerase Chain Reaction, Sequence Analysis, RNA, Zoonoses (diagnosis), Zoonoses (epidemiology), Zoonoses (virology).
MESH :
- chemical , analysis : RNA, Viral.
- diagnosis : Coronavirus Infections, Zoonoses.
- epidemiology : Coronavirus Infections, Qatar, Zoonoses.
- genetics : Coronavirus.
- isolation & purification : Coronavirus.
- veterinary : Coronavirus Infections, Disease Outbreaks.
- virology : Camelus, Coronavirus Infections, Disease Reservoirs, Zoonoses.
- Adult, Animals, Base Sequence, Humans, Male, Middle Aged, Molecular Sequence Data, Phylogeny, Reverse Transcriptase Polymerase Chain Reaction, Sequence Analysis, RNA.

Abstract

SummaryBackground

Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe lower respiratory tract infection in people. Previous studies suggested dromedary camels were a reservoir for this virus. We tested for the presence of MERS-CoV in dromedary camels from a farm in Qatar linked to two human cases of the infection in October, 2013.

Methods

We took nose swabs, rectal swabs, and blood samples from all camels on the Qatari farm. We tested swabs with RT-PCR, with amplification targeting the E gene (upE), nucleocapsid (N) gene, and open reading frame (ORF) 1a. PCR positive samples were tested by different MERS-CoV specific PCRs and obtained sequences were used for phylogentic analysis together with sequences from the linked human cases and other human cases. We tested serum samples from the camels for IgG immunofluorescence assay, protein microarray, and virus neutralisation assay.

Findings

We obtained samples from 14 camels on Oct 17, 2013. We detected MERS-CoV in nose swabs from three camels by three independent RT-PCRs and sequencing. The nucleotide sequence of an ORF1a fragment (940 nucleotides) and a 4·2 kb concatenated fragment were very similar to the MERS-CoV from two human cases on the same farm and a MERS-CoV isolate from Hafr-Al-Batin. Eight additional camel nose swabs were positive on one or more RT-PCRs, but could not be confirmed by sequencing. All camels had MERS-CoV spike-binding antibodies that correlated well with the presence of neutralising antibodies to MERS-CoV.

Interpretation

Our study provides virological confirmation of MERS-CoV in camels and suggests a recent outbreak affecting both human beings and camels. We cannot conclude whether the people on the farm were infected by the camels or vice versa, or if a third source was responsible.

Funding

European Union projects EMPERIE (contract number 223498), ANTIGONE (contract number 278976), and the VIRGO consortium.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106553

DOI: 10.1016/S1473-3099(13)70690-X
PubMed: 24355866
PubMed Central: 7106553

Affiliations:

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation</title>
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<author><name sortKey="Myers, Richard" sort="Myers, Richard" uniqKey="Myers R" first="Richard" last="Myers">Richard Myers</name>
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<author><name sortKey="Godeke, Gert Jan" sort="Godeke, Gert Jan" uniqKey="Godeke G" first="Gert-Jan" last="Godeke">Gert-Jan Godeke</name>
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<author><name sortKey="Farag, Elmoubasher" sort="Farag, Elmoubasher" uniqKey="Farag E" first="Elmoubasher" last="Farag">Elmoubasher Farag</name>
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<author><name sortKey="Diab, Ayman" sort="Diab, Ayman" uniqKey="Diab A" first="Ayman" last="Diab">Ayman Diab</name>
<affiliation wicri:level="1"><nlm:aff id="aff5">Supreme Council of Health, Doha, Qatar</nlm:aff>
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<wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea>
<wicri:noRegion>Doha</wicri:noRegion>
</affiliation>
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<author><name sortKey="Ghobashy, Hazem" sort="Ghobashy, Hazem" uniqKey="Ghobashy H" first="Hazem" last="Ghobashy">Hazem Ghobashy</name>
<affiliation wicri:level="1"><nlm:aff id="aff5">Supreme Council of Health, Doha, Qatar</nlm:aff>
<country xml:lang="fr">Qatar</country>
<wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea>
<wicri:noRegion>Doha</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Alhajri, Farhoud" sort="Alhajri, Farhoud" uniqKey="Alhajri F" first="Farhoud" last="Alhajri">Farhoud Alhajri</name>
<affiliation wicri:level="1"><nlm:aff id="aff5">Supreme Council of Health, Doha, Qatar</nlm:aff>
<country xml:lang="fr">Qatar</country>
<wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea>
<wicri:noRegion>Doha</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Al Thani, Mohamed" sort="Al Thani, Mohamed" uniqKey="Al Thani M" first="Mohamed" last="Al-Thani">Mohamed Al-Thani</name>
<affiliation wicri:level="1"><nlm:aff id="aff5">Supreme Council of Health, Doha, Qatar</nlm:aff>
<country xml:lang="fr">Qatar</country>
<wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea>
<wicri:noRegion>Doha</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Al Marri, Salih A" sort="Al Marri, Salih A" uniqKey="Al Marri S" first="Salih A" last="Al-Marri">Salih A. Al-Marri</name>
<affiliation wicri:level="1"><nlm:aff id="aff5">Supreme Council of Health, Doha, Qatar</nlm:aff>
<country xml:lang="fr">Qatar</country>
<wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea>
<wicri:noRegion>Doha</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Al Romaihi, Hamad E" sort="Al Romaihi, Hamad E" uniqKey="Al Romaihi H" first="Hamad E" last="Al Romaihi">Hamad E. Al Romaihi</name>
<affiliation wicri:level="1"><nlm:aff id="aff5">Supreme Council of Health, Doha, Qatar</nlm:aff>
<country xml:lang="fr">Qatar</country>
<wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea>
<wicri:noRegion>Doha</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Al Khal, Abdullatif" sort="Al Khal, Abdullatif" uniqKey="Al Khal A" first="Abdullatif" last="Al Khal">Abdullatif Al Khal</name>
<affiliation wicri:level="1"><nlm:aff id="aff5">Supreme Council of Health, Doha, Qatar</nlm:aff>
<country xml:lang="fr">Qatar</country>
<wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea>
<wicri:noRegion>Doha</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bermingham, Alison" sort="Bermingham, Alison" uniqKey="Bermingham A" first="Alison" last="Bermingham">Alison Bermingham</name>
<affiliation wicri:level="3"><nlm:aff id="aff4">Virus Reference Department, Public Health England, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Virus Reference Department, Public Health England, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D M E" last="Osterhaus">Albert D M E. Osterhaus</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Alhajri, Mohd M" sort="Alhajri, Mohd M" uniqKey="Alhajri M" first="Mohd M" last="Alhajri">Mohd M. Alhajri</name>
<affiliation wicri:level="1"><nlm:aff id="aff5">Supreme Council of Health, Doha, Qatar</nlm:aff>
<country xml:lang="fr">Qatar</country>
<wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea>
<wicri:noRegion>Doha</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Koopmans, Marion P G" sort="Koopmans, Marion P G" uniqKey="Koopmans M" first="Marion P G" last="Koopmans">Marion P G. Koopmans</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3">Centre for Infectious Disease Research, Diagnostics and Screening, Division of Virology, National Institute for Public Health and the Environment, Bilthoven, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Centre for Infectious Disease Research, Diagnostics and Screening, Division of Virology, National Institute for Public Health and the Environment, Bilthoven</wicri:regionArea>
<wicri:noRegion>Bilthoven</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">The Lancet. Infectious Diseases</title>
<idno type="ISSN">1473-3099</idno>
<idno type="eISSN">1474-4457</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Animals</term>
<term>Base Sequence</term>
<term>Camelus (virology)</term>
<term>Coronavirus (genetics)</term>
<term>Coronavirus (isolation & purification)</term>
<term>Coronavirus Infections (diagnosis)</term>
<term>Coronavirus Infections (epidemiology)</term>
<term>Coronavirus Infections (veterinary)</term>
<term>Coronavirus Infections (virology)</term>
<term>Disease Outbreaks (veterinary)</term>
<term>Disease Reservoirs (virology)</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Molecular Sequence Data</term>
<term>Phylogeny</term>
<term>Qatar (epidemiology)</term>
<term>RNA, Viral (analysis)</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
<term>Sequence Analysis, RNA</term>
<term>Zoonoses (diagnosis)</term>
<term>Zoonoses (epidemiology)</term>
<term>Zoonoses (virology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (analyse)</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de séquence d'ARN</term>
<term>Animaux</term>
<term>Chameaux (virologie)</term>
<term>Coronavirus (génétique)</term>
<term>Coronavirus (isolement et purification)</term>
<term>Données de séquences moléculaires</term>
<term>Flambées de maladies (médecine vétérinaire)</term>
<term>Humains</term>
<term>Infections à coronavirus (diagnostic)</term>
<term>Infections à coronavirus (médecine vétérinaire)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Infections à coronavirus (épidémiologie)</term>
<term>Mâle</term>
<term>Phylogénie</term>
<term>Qatar (épidémiologie)</term>
<term>RT-PCR</term>
<term>Réservoirs d'agents pathogènes (virologie)</term>
<term>Séquence nucléotidique</term>
<term>Zoonoses (diagnostic)</term>
<term>Zoonoses (virologie)</term>
<term>Zoonoses (épidémiologie)</term>
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</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term>
<term>Zoonoses</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Zoonoses</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Qatar</term>
<term>Zoonoses</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Flambées de maladies</term>
<term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Coronavirus Infections</term>
<term>Disease Outbreaks</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Chameaux</term>
<term>Infections à coronavirus</term>
<term>Réservoirs d'agents pathogènes</term>
<term>Zoonoses</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Camelus</term>
<term>Coronavirus Infections</term>
<term>Disease Reservoirs</term>
<term>Zoonoses</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Qatar</term>
<term>Zoonoses</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Animals</term>
<term>Base Sequence</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Molecular Sequence Data</term>
<term>Phylogeny</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
<term>Sequence Analysis, RNA</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de séquence d'ARN</term>
<term>Animaux</term>
<term>Données de séquences moléculaires</term>
<term>Humains</term>
<term>Mâle</term>
<term>Phylogénie</term>
<term>RT-PCR</term>
<term>Séquence nucléotidique</term>
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<front><div type="abstract" xml:lang="en"><title>Summary</title>
<sec><title>Background</title>
<p>Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe lower respiratory tract infection in people. Previous studies suggested dromedary camels were a reservoir for this virus. We tested for the presence of MERS-CoV in dromedary camels from a farm in Qatar linked to two human cases of the infection in October, 2013.</p>
</sec>
<sec><title>Methods</title>
<p>We took nose swabs, rectal swabs, and blood samples from all camels on the Qatari farm. We tested swabs with RT-PCR, with amplification targeting the <italic>E</italic>
 gene (upE), nucleocapsid (<italic>N</italic>
) gene, and open reading frame (ORF) 1a. PCR positive samples were tested by different MERS-CoV specific PCRs and obtained sequences were used for phylogentic analysis together with sequences from the linked human cases and other human cases. We tested serum samples from the camels for IgG immunofluorescence assay, protein microarray, and virus neutralisation assay.</p>
</sec>
<sec><title>Findings</title>
<p>We obtained samples from 14 camels on Oct 17, 2013. We detected MERS-CoV in nose swabs from three camels by three independent RT-PCRs and sequencing. The nucleotide sequence of an ORF1a fragment (940 nucleotides) and a 4·2 kb concatenated fragment were very similar to the MERS-CoV from two human cases on the same farm and a MERS-CoV isolate from Hafr-Al-Batin. Eight additional camel nose swabs were positive on one or more RT-PCRs, but could not be confirmed by sequencing. All camels had MERS-CoV spike-binding antibodies that correlated well with the presence of neutralising antibodies to MERS-CoV.</p>
</sec>
<sec><title>Interpretation</title>
<p>Our study provides virological confirmation of MERS-CoV in camels and suggests a recent outbreak affecting both human beings and camels. We cannot conclude whether the people on the farm were infected by the camels or vice versa, or if a third source was responsible.</p>
</sec>
<sec><title>Funding</title>
<p>European Union projects EMPERIE (contract number 223498), ANTIGONE (contract number 278976), and the VIRGO consortium.</p>
</sec>
</div>
</front>
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</TEI>
<affiliations><list><country><li>Pays-Bas</li>
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<li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
<li>Hollande-Méridionale</li>
</region>
<settlement><li>Londres</li>
<li>Rotterdam</li>
</settlement>
</list>
<tree><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name>
</region>
<name sortKey="Godeke, Gert Jan" sort="Godeke, Gert Jan" uniqKey="Godeke G" first="Gert-Jan" last="Godeke">Gert-Jan Godeke</name>
<name sortKey="Jonges, Marcel" sort="Jonges, Marcel" uniqKey="Jonges M" first="Marcel" last="Jonges">Marcel Jonges</name>
<name sortKey="Koopmans, Marion P G" sort="Koopmans, Marion P G" uniqKey="Koopmans M" first="Marion P G" last="Koopmans">Marion P G. Koopmans</name>
<name sortKey="Koopmans, Marion P G" sort="Koopmans, Marion P G" uniqKey="Koopmans M" first="Marion P G" last="Koopmans">Marion P G. Koopmans</name>
<name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D M E" last="Osterhaus">Albert D M E. Osterhaus</name>
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</country>
<country name="Qatar"><noRegion><name sortKey="Al Dhahiry, Said H S" sort="Al Dhahiry, Said H S" uniqKey="Al Dhahiry S" first="Said H S" last="Al Dhahiry">Said H S. Al Dhahiry</name>
</noRegion>
<name sortKey="Al Khal, Abdullatif" sort="Al Khal, Abdullatif" uniqKey="Al Khal A" first="Abdullatif" last="Al Khal">Abdullatif Al Khal</name>
<name sortKey="Al Marri, Salih A" sort="Al Marri, Salih A" uniqKey="Al Marri S" first="Salih A" last="Al-Marri">Salih A. Al-Marri</name>
<name sortKey="Al Romaihi, Hamad E" sort="Al Romaihi, Hamad E" uniqKey="Al Romaihi H" first="Hamad E" last="Al Romaihi">Hamad E. Al Romaihi</name>
<name sortKey="Al Thani, Mohamed" sort="Al Thani, Mohamed" uniqKey="Al Thani M" first="Mohamed" last="Al-Thani">Mohamed Al-Thani</name>
<name sortKey="Alhajri, Farhoud" sort="Alhajri, Farhoud" uniqKey="Alhajri F" first="Farhoud" last="Alhajri">Farhoud Alhajri</name>
<name sortKey="Alhajri, Mohd M" sort="Alhajri, Mohd M" uniqKey="Alhajri M" first="Mohd M" last="Alhajri">Mohd M. Alhajri</name>
<name sortKey="Diab, Ayman" sort="Diab, Ayman" uniqKey="Diab A" first="Ayman" last="Diab">Ayman Diab</name>
<name sortKey="Farag, Elmoubasher" sort="Farag, Elmoubasher" uniqKey="Farag E" first="Elmoubasher" last="Farag">Elmoubasher Farag</name>
<name sortKey="Ghobashy, Hazem" sort="Ghobashy, Hazem" uniqKey="Ghobashy H" first="Hazem" last="Ghobashy">Hazem Ghobashy</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Galiano, Monica" sort="Galiano, Monica" uniqKey="Galiano M" first="Monica" last="Galiano">Monica Galiano</name>
</region>
<name sortKey="Bermingham, Alison" sort="Bermingham, Alison" uniqKey="Bermingham A" first="Alison" last="Bermingham">Alison Bermingham</name>
<name sortKey="Myers, Richard" sort="Myers, Richard" uniqKey="Myers R" first="Richard" last="Myers">Richard Myers</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001F43 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001F43 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    MersV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:7106553
   |texte=   Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:24355866" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a MersV1

This area was generated with Dilib version V0.6.33.
Data generation: Mon Apr 20 23:26:43 2020. Site generation: Sat Mar 27 09:06:09 2021

Serveur d'exploration MERS

Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation

Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration MERS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.